Lilly再出手,5.75亿美元收购肿瘤药企业AurKa Pharma,获得Aurora激酶抑制剂AK-01


#LLY


正在布局抗肿瘤药产品线的Lilly继续发力

继收购Armo BioSciences之后

今日又宣布收购AurKa Pharma

1.1亿美元首付款

外加4.65亿美元的里程碑款项

以及一定的销售额分成

AurKa Pharma

2016年成立于加拿大蒙特利尔

TVM Capital Life Science Venture Capital第十二个投资项目

成立之初

正是旨在开发Lilly旗下抗肿瘤活性化合物

也是此次看中的为Aurora激酶抑制剂AK-01

目前处于临床I期研究中


Aurora激酶主要参与调节中心体和微管的功能

以保证染色体的精确分离和胞质的有效分离

通常都在G2-M期达到高峰

调节着细胞周期中G2-M转换

是调节M期进展的关键因子



Aurora激酶由3个亚群组组成

Aurora-A、Aurora-B和Aurora-C

此时的过表达则导致遗传的不稳定性

造成细胞多倍体诱发恶性肿瘤

AurKa旗下的AK-01对Aurora-A有高度选择性

临床I期试验也证明了潜在的临床收益

后续临床将继续评估临床收益与风险的结果


Darren Carroll
Senior vice president of corporate business development at Lilly

The acquisition of AurKa Pharma supports Lilly's external innovation strategy, in which we seek to partner with leading life science venture capital firms in order to identify, support and access promising innovation in areas of unmet medical need. We are excited with the value TVM created for this compound through its early-Phase studies, and we look forward to more opportunities in the future.


Luc Marengere, Ph.D.
Managing Partner at TVM Capital Life Science

Through the unique healthcare venture capital model pioneered by TVM Capital Life Science, companies such as AurKa have been established to more quickly and efficiently bring promising compounds to clinical proof-of-concept. We are pleased that the scientific advances made by AurKa could contribute to the development of AK-01 and hopefully help deliver a potential new medicine for cancer patients.





Takeda在2015年终止了Aurora A抑制剂Alisertib

用于复发或难治性外周T细胞淋巴瘤III期临床研究

但SCLC二线临床II期研究还在等待

而AK-01此前的临床I期研究中

选择的是小细胞肺癌、乳腺癌和头颈癌适应症的二线用药

Lilly这一步棋走的有点意思

当然这个收购之路还将继续

4-5笔刚完成2笔